1 Apple - iPhone Following a big buzz around its launch, the iPhone became this year's hottest new item, selling more than a million units to date. The sleek, aesthetic design and Web 2.0 capabilities made it an instant techie favorite.
2 High School Musical 2 - The sequel to the mega-hit original film, HSM2 had 17.2 million fans of all ages glued to the screen.
3 Harry Potter and the Deathly Hallows - The seventh and last book from the series caused a cycle of book parties nationwide. Diehard fans purchased 11 million copies in the first 24 hours. The book also went global in 93 countries.
4 Alli - A huge marketing blitz helped drive dieters to pick up the first and only FDA approved over-the-counter weight-loss pill. Sales have surpassed $150 million to date, proving that unpleasant side effects won't deter Americans from shrinking their pant size.
5 Halo 3 - This Microsoft launch set a new US record for opening-day sales by an entertainment property - $170 million. It made the covers of Time and Rolling Stone, too.
6 Google Android - Google generated buzz for its new mobile platform, slated to launch in 2008, by releasing a software developer kit that offers a peek at what it might look like.
7 Portfolio - Conde Nast launched the glossy business mag with the intention to spice up business reporting. Several issues in, many are still wondering if its editorial content can catch up to its ad sales.
8 A380 - The new Airbus took flight with the media when it launched the world's largest commercial passenger jet. For its US debut, there were about 120 news media outlets at JFK, 40 at O'Hare, and more than 200 accredited media personnel at LAX.
9 Microsoft Windows Vista - One of Microsoft's biggest consumer launches ever included appearances by Bill Gates on both Today and The Daily Show with Jon Stewart.
10 XO Computer - Nicholas Negroponte's nonprofit One Laptop per Child is averaging $2 million a day in donations since introducing the first low-cost, energy efficient computer designed for children in developing nations.